Publications
Read our latest research and peer-reviewed publications.
Peer Reviewed
2026
A Large Concept Model for Mechanistic Simulation of Disease Trajectories: A Hypothesis-Generating Exemplar for Pediatric Acute Lymphoblastic Leukemia
View Publication2026
Application of aiAtlas Version 1.2 to Simulate Variant Gene Function Restoration and Rescue Thresholds in Rare Diseases: Validation Case Study
View Publication2026
aiHumanoid v11.9: a large concept model for autonomous ethical reasoning in clinical AI
View Publication2021
Artificially Induced Pluripotent Stem Cell-Derived Whole-Brain Organoid for Modelling the Pathophysiology of Metachromatic Leukodystrophy and Drug Repurposing
View Publication2021
Lung organoid simulations for modelling and predicting the effect of mutations on SARS-CoV-2 infectivity
View Publication2021
Stem‐cell based, machine learning approach for optimizing natural killer cell‐based personalized immunotherapy for high‐grade ovarian cancer
View Publication2021
NEUBOrg: Artificially Induced Pluripotent Stem Cell-Derived Brain Organoid to Model and Study Genetics of Alzheimer’s Disease Progression
View Publication2020
Viral pandemic preparedness: A pluripotent stem cell-based machine-learning platform for simulating SARS-CoV-2 infection to enable drug discovery and repurposing
View Publication2019
DeepNEU: cellular reprogramming comes of age–a machine learning platform with application to rare diseases research
View Publication2019
DeepNEU: artificially induced stem cell (aiPSC) and differentiated skeletal muscle cell (aiSkMC) simulations of infantile onset POMPE disease (IOPD) for potential biomarker identification and drug discovery
View PublicationPreprints
2026
Genotype- and Age-Specific Relapse Dynamics in Childhood Acute Lymphoblastic Leukemia: A Longitudinal Mechanistic Study
View Publication2025
aiAtlas: High-Fidelity Cell Simulations of Genetic Perturbations in Rare Diseases and Cancers
View Publication2024
aiHumanoid Simulations Uncover Dominant-Negative Effects in HNRNPH2-Related Neurodevelopmental Disorders
View Publication2024
Tracing Alzheimer’s Genetic Footprints: A Pioneering Longitudinal Study Using Artificial Intelligence to Unravel Mutation-Driven Risks and Progression in Virtual Patients; Part 1–The APOE genotypes
View Publication2024
Investigating Genetic and Familial Risks in Childhood ALL: A Longitudinal Virtual Study Using aiHumanoid Simulations of TEL-AML1 Gene Fusion
View Publication2024
Evaluating the Efficacy of Miglustat and Ambroxol Combination Therapy in a Phase 1b/2 Virtual Drug Trial for Type 1 Tay-Sachs Disease Using aiHumanoid Simulations
View Publication2024
Age-Dependent Effects of UV Exposure and Xeroderma Pigmentosum Group A on DNA Damage, Repair Mechanisms, Genomic Instability, Cancer Risk, and Neurological Disorders
View Publication2023
HAI-VECT (SCD): AI-Humanoid Enabled Virtual Clinical Trial for Sickle Cell Disease
View Publication2023
An aiHumanoid Simulation of Gram-Negative Sepsis: A Comprehensive Multi-Organoid Platform for Advanced Disease Modeling, Drug Discovery, and Personalized Medicine
View Publication2023
Advancing Drug Development with aiHumanoid Simulations: A Virtual Phase 1 Comparative Study of Standard Chemotherapy versus Standard Chemotherapy plus COTI-2 for Pancreatic Adenocarcinoma
View Publication2022
Nipah Pandemic Preparedness: Machine Leaning-Derived Whole Brain Organoid Simulations for Identifying Optimal Vaccine Candidates Against the Nipah Virus
View Publication2022
DeepNEU©: Introducing aiCRISPRL, a hybrid AI stem cell and organoid simulation platform with broad gene editing capabilities and applications
View Publication2021
DeepNEU: a machine learning platform for simulating Cytokine Storm and Coagulopathy that complicate severe COVID-19 to enable targeted drug repurposing
View Publication2020